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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IRS2 All Species: 4.55
Human Site: Y576 Identified Species: 9.09
UniProt: Q9Y4H2 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y4H2 NP_003740.2 1338 137334 Y576 R G L R K R T Y S L T T P A R
Chimpanzee Pan troglodytes XP_529580 1133 115941 L416 L R K R T Y S L T T P A R Q R
Rhesus Macaque Macaca mulatta XP_001109882 1252 133053 T533 H S A G T S P T I T H Q K T P
Dog Lupus familis XP_542667 1132 119070 A415 S I A E T P P A R D G G G G E
Cat Felis silvestris
Mouse Mus musculus P81122 1321 136508 Y572 R G L R K R T Y S L T T P A R
Rat Rattus norvegicus P35570 1235 131160 K518 D L D N R F R K R T H S A G T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505439 368 40215
Chicken Gallus gallus XP_425588 735 76788 D18 R G P V L P R D T V P P Q R P
Frog Xenopus laevis P84770 1088 119088 I371 P L N H S R S I P M P A T R C
Zebra Danio Brachydanio rerio XP_700746 1062 115299 R345 V N R T H L S R S N T V T A R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9XTN2 968 107813 H251 Q N R P D L S H E P M R K R S
Honey Bee Apis mellifera XP_391985 1190 129451 I473 P P I S S M P I S P A S G A C
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.5 36.8 75.6 N.A. 85.1 36 N.A. 20.3 35.2 38.1 49.4 N.A. 21 21 N.A. N.A.
Protein Similarity: 100 83.3 48.8 77.5 N.A. 88 48.1 N.A. 23.1 42.5 49.7 59.3 N.A. 35.9 35.7 N.A. N.A.
P-Site Identity: 100 13.3 0 0 N.A. 100 0 N.A. 0 13.3 6.6 26.6 N.A. 0 13.3 N.A. N.A.
P-Site Similarity: 100 26.6 0 0 N.A. 100 13.3 N.A. 0 26.6 20 33.3 N.A. 20 26.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 17 0 0 0 0 9 0 0 9 17 9 34 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17 % C
% Asp: 9 0 9 0 9 0 0 9 0 9 0 0 0 0 0 % D
% Glu: 0 0 0 9 0 0 0 0 9 0 0 0 0 0 9 % E
% Phe: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 25 0 9 0 0 0 0 0 0 9 9 17 17 0 % G
% His: 9 0 0 9 9 0 0 9 0 0 17 0 0 0 0 % H
% Ile: 0 9 9 0 0 0 0 17 9 0 0 0 0 0 0 % I
% Lys: 0 0 9 0 17 0 0 9 0 0 0 0 17 0 0 % K
% Leu: 9 17 17 0 9 17 0 9 0 17 0 0 0 0 0 % L
% Met: 0 0 0 0 0 9 0 0 0 9 9 0 0 0 0 % M
% Asn: 0 17 9 9 0 0 0 0 0 9 0 0 0 0 0 % N
% Pro: 17 9 9 9 0 17 25 0 9 17 25 9 17 0 17 % P
% Gln: 9 0 0 0 0 0 0 0 0 0 0 9 9 9 0 % Q
% Arg: 25 9 17 25 9 25 17 9 17 0 0 9 9 25 34 % R
% Ser: 9 9 0 9 17 9 34 0 34 0 0 17 0 0 9 % S
% Thr: 0 0 0 9 25 0 17 9 17 25 25 17 17 9 9 % T
% Val: 9 0 0 9 0 0 0 0 0 9 0 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 9 0 17 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _